hLRRC15/MC-38
CBPG0108
询 价
留 言
产品描述
产品数据库
| I. Background | |
| LRRC15（Leucine Rich Repeat Containing 15），富含 15 个亮氨酸的重复序列，是 LRRC 超家族的成员之一。LRRC15 同时能够正调控细胞的迁移，调控受体介导的病毒粒子与宿主细胞的附着，且蛋白质定位于细胞质膜。LRRC15 主要是以蛋白-蛋白和蛋白-基质 相互作用方式，参与细胞-细胞和/或-细胞外基质的相互作用，参与炎性反应相关疾病，同时在细胞粘附、信号转导、DNA 修复等过程中有重要作用。LRRC15 在正常组织中的低表达，而在骨肉瘤、卵巢癌、乳腺癌、胰腺导管腺癌、促结缔组织增生型小圆细胞癌等癌症 中高表达。 | |
| II. Introduction | |
| Host Cell: | MC-38 |
| Expressed gene: | hLRRC15 |
| Stability: | 32 passages |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | DMEM+10%FBS+5μg/ml Puromycin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| III. Description of Host Cell Line | |
| Organism: | Mouse |
| Tissue: | Colon |
| Morphology: | Epitheloid cell |
| Growth Properties: | Adherent |
| IV. Representative Data | |
|
|
|
| V. In VIVO Data | |
|
Index |
Content |
|
Animal |
C57BL/6J, 6weeks, female |
|
Implanted Position |
Subcutaneous (right lower flank region) |
|
Injected Cell Numbers |
1×10^6/0.1ml |
|
Matrix gel |
Without matrix gel |
1. Weight Change
Figure 2. hLRRC15/MC38 Mean Body Weight ± SEM.
2. Tumor Volume
Figure 3. hLRRC15/MC38 Mean Tumor Volume ± SEM.
NOTE：The above data was provided by Cobioer (cell data) and Truway Bio (in vivo data model).
